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2012, Volume 23, number 10

G-Protein-Coupled Receptors: the 2012 Nobel Prize in Chemistry

The Royal Swedish Academy of Sciences awarded the 2012 Nobel Prize in Chemistry to the U.S. researchers Robert J. Lefkowitz, fom the Duke University Medical Center (North Carolina, USA) and to Brian K. Kobilka, from the Stanford University School of Medicine (California, USA) for their studies on the G-protein-coupled receptors (GPCRs).

(Read more at Editorial)


Suppression of the Hemolytic Effect of Mesoporous Silica Nanoparticles after
Protein Corona Interaction: Independence of the Surface Microchemical Environment
Amauri J. Paula, Diego Stéfani T. Martinez, Roberto T. Araujo Júnior, Antonio G. Souza Filho and Oswaldo L. Alves

The effects induced by nanoparticles interacting in biological fluids and with blood cells were determined by fine and selective chemical interactions between these materials in nanoscale and biomolecules. In this context, understanding and controlling these interactions will be crucial to pave the way towards the application of nanomaterials in nanomedicine and nanotoxicology. Details are discussed in the Article by Paula et al. on page 1807. (link below)

>> Editorial (347 KB)
G-Protein-Coupled Receptors: the 2012 Nobel Prize in Chemistry
Adriano D. Andricopulo and Glaucius Oliva
J. Braz. Chem. Soc. 2012, 23, 1767.


Synthesis, Crystal Structure and Biological Activity of Novel Diester Cyclophanes
Pengfei Zhang, Bingqin Yang, Xianwen Fang, Zhao Cheng and Meipan Yang
J. Braz. Chem. Soc. 2012, 23, 1771.

Several novel cyclophanes were synthesized by esterification reactions under high dilution conditions. Some of these compounds have low antifungal or antibacterial activities
>> PDF (1.59 MB) / Supplementary Information (963 KB)
DOI S0103-505320120050000045                                                Published online: September 25, 2012

Spatial Structure of Eugenia dysenterica Based on Essential Oil Chemovariations and Implications for Conservation and Management of the Genetic Diversity of its Populations
Eliane C. Vilela, Thays C. Carvalho, Alessandra R. Duarte, Ronaldo R. Naves, Suzana C. Santos,
José C. Seraphin and Pedro H. Ferri
J. Braz. Chem. Soc. 2012, 23, 1776.

Essential oils were used to study the spatial structure of eight Eugenia dysenterica populations in central Brazilian Cerrado. Differential patterns can be explained by the distinct spatial rearrangement of the populations and may contribute to the species management and conservation based only on oil chemovariations

>> PDF (484 KB) /Supplementary Information (1,80 MB)
DOI S0103-505320120050000043                                                Published online: September 25, 2012

Biosynthesis of Two Dihydropyrrole-Polyketides from a Marine-Derived
Penicillium citrinum
Stelamar Romminger, Eli F. Pimenta, Eduardo S. Nascimento, Antonio G. Ferreira and
Roberto G. S. Berlinck
J. Braz. Chem. Soc. 2012, 23, 1783.

Feeding experiments using 13C-labeled precursors were performed aim at investigating the biosynthesis of two dihydropyrrole-polyketides isolated from a marine-derived Penicillium citrinum. The results showed that the biosynthesis proceeds from acetate, methionine and ornithine
>> PDF (315 KB) /Supplementary Information (555 KB)
DOI S0103-505320120050000046                                                Published online: September 28, 2012

Probing Topological Electronic Effects in Catalysis: Thiophene Adsorption on NiMoS and CoMoS Clusters
Itamar Borges Jr. and Alexander M. Silva
J. Braz. Chem. Soc. 2012, 23, 1789.

Thiophene adsorbed on NiMoS and CoMoS catalysts was studied with density functional theory and a topological approach to probe electronic modifications. The origin of the promoter effect, an enhancement of hydrodesulfurization activity due to weaking of metal-sulfur bond strengths, was explained
>> PDF (877 KB) / Supplementary Information (205 KB)
DOI S0103-505320120050000044                                                Published online: September 28, 2012

Determination of Sildenafil Citrate (Viagra®) in Various Pharmaceutical Formulations by Flow Injection Analysis with Multiple Pulse Amperometric Detection
Antônio Carlos V. Lopes Júnior, Rita de Cássia Silva Luz, Flávio S. Damos, Alexandre S. dos Santos, Diego L. Franco and Wallans T. Pio dos Santos
J. Braz. Chem. Soc. 2012, 23, 1800.
Fast and low-cost methodology for the determination of sildenafil in different types of pharmaceutical samples using a flow injection analysis (FIA) system with multiple pulse amperometric detection on a boron-doped diamond electrode is presented. Excellent reproducibility and high analytical frequency were obtained under these conditions
>> PDF (756 KB)
DOI S0103-505320120050000047                                                Published online: September 28, 2012

Suppression of the Hemolytic Effect of Mesoporous Silica Nanoparticles after
Protein Corona Interaction: Independence of the Surface Microchemical Environment
Amauri J. Paula, Diego Stéfani T. Martinez, Roberto T. Araujo Júnior, Antonio G. Souza Filho and Oswaldo L. Alves
J. Braz. Chem. Soc. 2012, 23, 1807. (cover article)

Bare porous silica nanoparticles induce hemolysis in human red blood cells, while protein coated nanoparticles resulted from their interaction with blood plasma (the so called protein corona effect) completely prevent the hemolytic effect
>> PDF (2,37 MB) /Supplementary Information (728 KB)
DOI S0103-505320120050000048                                                      Published online: October 2, 2012

Evaluation of Chemical Changes during Myrciaria cauliflora (Jabuticaba Fruit) Fermentation by 1H NMR Spectroscopy and Chemometric Analyses
Gilmara A. C. Fortes, Sara S. Naves, Pedro H. Ferri and Suzana C. Santos
J. Braz. Chem. Soc. 2012, 23, 1815.

Metabolites were monitored during jabuticaba fermentation by 1H nuclear magnetic resonance and spectrophotometric assays. Multivariate methods revealed the influences of alcohols and organic acids on the extraction and stability of phenols and color properties
>> PDF (631 KB) /Supplementary Information (205 KB)
DOI S0103-505320120050000050                                                      Published online: October 2, 2012

Influence of Abiotic Factors on the Chemical Composition of Copaiba Oil (Copaifera multijuga Hayne): Soil Composition, Seasonality and
Diameter at Breast Height
Paula C. S. Barbosa, Raquel S. Medeiros, Paulo T. B. Sampaio, Gil Vieira,
Larissa S. M. Wiedemann and Valdir F. Veiga-Junior
J. Braz. Chem. Soc. 2012, 23, 1823.

The chemical composition of copaiba oils (Copaifera multijuga Hayne) is affected by soil characteristics, but not seasonality or diameter at breast height (DBH). Cluster analysis shows that caryophyllene and its oxide form the main groups
>> PDF (677 KB)
DOI S0103-505320120050000049                                                      Published online: October 5, 2012

Fast Determination of Naproxen in Pharmaceutical Formulations by Batch Injection Analysis with Pulsed Amperometric Detection
Jessica S. Stefano, Ana Paula de Lima, Rodrigo H. O. Montes, Eduardo M. Richter
and Rodrigo A. A. Muñoz
J. Braz. Chem. Soc. 2012, 23, 1834.

A fast method for naproxen determination in pharmaceutical formulations using batch injection analysis with pulsed amperometric detection is presented. High analytical frequency (90 h-1), satisfactory accuracy and low limit of detection (0.3 μmol L-1) were obtained
>> PDF (451 KB)
DOI S0103-505320120050000055                                                      Published online: October 9, 2012

Synthesis of N -Substituted Phthalimidoalkyl 1H -1,2,3-Triazoles: a Molecular Diversity Combining Click Chemistry and Ultrasound Irradiation
Moara T. da Silva, Ronaldo N. de Oliveira, Wagner O. Valença, Fernanda C. G. Barbosa,
Mauro G. da Silva and Celso A. Camara
J. Braz. Chem. Soc. 2012, 23, 1839.
N-substituted phthalimidoalkyl 1H-1,2,3-triazoles were obtained in good-to-excellent yields (67-98%) through click chemistry protocol (Cu-AAC) at room temperature using DMF, Et3N under ultrasound irradiation
>> PDF (296 KB) /Supplementary Information (1,33 MB)
DOI S0103-505320120050000053                                                     Published online: October 11, 2012

Chemotaxonomic Markers in Essential Oils of Hypenia (Mart. ex Benth.) R. Harley
Maria T. Faria, Deomar P. Costa, Eliane C. Vilela, Dalva G. Ribeiro, Heleno D. Ferreira,
Suzana C. Santos, José C. Seraphin and Pedro H. Ferri
J. Braz. Chem. Soc. 2012, 23, 1844.

Essential oil chemovariations in the genus Hypenia suggest that cadinanes and bicyclo-germacranes/aromadendranes are chemomarkers of sections Densiflorae and Laxiflorae, respectively
>> PDF (543 KB) /Supplementary Information (545 KB)
DOI S0103-505320120050000056                                                     Published online: October 11, 2012

7,8-Secolignans from Schisandra neglecta and Their Anti-HIV-1 Activities
Xuemei Gao, Huaixue Mu, Ruirui Wang, Qiufen Hu, Liumeng Yang, Yongtang Zheng, Handong Sun
and Weilie Xiao
J. Braz. Chem. Soc. 2012, 23, 1853.

Four new 7,8-secolignans (neglectahenols A-D) were isolated from leaves and stems of Schisandra neglecta, and neglectahenols A-D showed modest anti HIV-1 (human immuno-deficiency virus type 1) activities with therapeutic index (TI) values of 58.65, 26.36, 23.71 and 25.85, respectively
>> PDF (309 KB) /Supplementary Information (696 kB)
DOI S0103-505320120050000054                                                     Published online: October 11, 2012

Synthesis of LaNiO3 Perovskite by the Modified Proteic Gel Method and Study of Catalytic Properties in the Syngas Production
José C. Santos, Marcelo J. B. Souza, Juan A. C. Ruiz, Dulce M. A. Melo, Maria E. Mesquita
and Anne M. Garrido Pedrosa
J. Braz. Chem. Soc. 2012, 23, 1858.

The temperature programmed reduction analysis of LaNiO3 and LaNiO3/Al2O3 showed that the Ni3+ of perovskite structure reduced in two steps and the peaks correspond to successive changes in the structure, which are related to reduction: Ni3+ to Ni2+ and Ni2+ to Ni0
>> PDF (412 KB)
DOI S0103-505320120050000052                                                     Published online: October 11, 2012

Decolorization of Textile Dyes by Cyanobacteria
Maria Estela Silva-Stenico, Felipe D. P. Vieira, Diego B. Genuário, Caroline S. P. Silva,
Luiz Alberto B. Moraes and Marli Fátima Fiore
J. Braz. Chem. Soc. 2012, 23, 1863.

The use of cyanobacteria to decolorize and possibly to degrade eleven types of textile dyes was confirmed by mass spectrometry and resulted in completely textile dye remotion
>> PDF (1,25 MB) /Supplementary Information (1,04 MB)
DOI S0103-505320120050000058                                                     Published online: October 16, 2012

Solar Radiation Effect on the Complexation Capacity of Aquatic Humic Substances with Metals
Camila A. Melo, Ana L. De Toffoli, Altair B. Moreira and Márcia C. Bisinoti
J. Braz. Chem. Soc. 2012, 23, 1871.

The effect of solar radiation in the complexation capacity of aquatic humic substances (AHS) with Al3+, Cr3+, CrO42- and Ni2+ was evaluated. AHS were extracted and characterized employing conventional techniques
>> PDF (659 kB)
DOI S0103-505320120050000035                                                     Published online: October 19, 2012

A Study of Asphaltene-Resin Interactions
Luiz C. C. Marques, Juliana O. Pereira, André D. Bueno, Valdo S. Marques, Elizabete F. Lucas,
Claudia R. E. Mansur, A. L. C. Machado and Gaspar González
J. Braz. Chem. Soc. 2012, 23, 1880.

Asphaltic materials recovered from a subsea petroleum production flowline during a pigging operation in Santos Basin, Santa Catarina State, Brazil

>> PDF (880 kB)
DOI S0103-505320120050000060                                                     Published online: October 19, 2012

Simultaneous Separation of Ciprofloxacin, Norfloxacin and Ofloxacin by
Micellar Electrokinetic Chromatography
Gabriel Hancu, Aura Rusu, Brigitta Simon, Georgiana Boia and Árpád Gyéresi
J. Braz. Chem. Soc. 2012, 23, 1889.

The article studies the electrophoretic behavior of the most frequently used fluoroquinolones (structurally related ciprofloxacin, norfloxacin and ofloxacin) in order to achieve their simultaneous separation from complex mixtures, by means of capillary zone electrophoresis respectively MEKC
>> PDF (783 kB)
DOI S0103-505320120050000057                                                    Published online: October 19, 2012

A Simple Method to Evaluate, Correlate and Predict Boiling and Flash Points of Alkynes
Justin M. Godinho, Felix A. Carroll and Frank H. Quina
J. Braz. Chem. Soc. 2012, 23, 1895.

Experimental boiling point numbers (YBP) of alkynes can be used to evaluate literature boiling point data, and YBP values calculated from simple structure counts can be used to predict alkyne boiling and flash points
>> PDF (340 KB) /Supplementary Information (354 KB)
DOI S0103-505320120050000064                                                    Published online: October 23, 2012

Photocatalytic Decomposition of Phenol by Nanocomposite of ZnS Nanoparticles and Montmorillonite
Petr Praus, Jakub Matys and Ondrej Kozák
J. Braz. Chem. Soc. 2012, 23, 1900.

ZnS nanoparticles were deposited on montmorillonite forming a stable nanocomposite, which was used as a catalyst for the photodecomposition of phenol. Reaction kinetics agreed with the pseudo-first reaction model confirming that the high amounts of hydroxyl radicals were produced. The catalytic activity of montmorillonite was not observed
>> PDF (441 KB)
DOI S0103-505320120050000063                                                    Published online: October 23, 2012

Absolute Quantification of Fatty Acid and Proximate Composition of Cow and Goat Powdered Milks
Weliton P. Batiston, Swami A. Maruyama, Sandra T. M. Gomes, Jesuí V. Visentainer, Nilson E. de Souza and Makoto Matsushita
J. Braz. Chem. Soc. 2012, 23, 1907.

Thermal processes applied in foods can lead to a loss of their nutritional quality due to the oxidation of their polyunsaturated fatty acids. Thus, the main objective of the present study is the absolute quantification of fatty acids from cow and goat powdered milks, through the application of gas chromatography with a flame ionization detector (GC-FID)
>> PDF (458 KB)
DOI S0103-505320120050000061                                                    Published online: October 26, 2012

Seasonal Distribution of Airborne Trace Elements and Water-Soluble Ions
in São Paulo Megacity, Brazil
Gisele O. Da Rocha, Pérola C. Vasconcellos, Simone G. Ávila, Davi Z. Souza, Eduardo A. O. Reis,
Pedro V. Oliveira and Odon Sanchez-Ccoyllo
J. Braz. Chem. Soc. 2012, 23, 1915.
This work describes the seasonal distribution of important constituents of PM10 particles (particulate matter less than 10 μm in diameter; major ions and trace elements) in São Paulo Megacity, Brazil. Predominant sources were fuel burning, biomass burning, gas-to-particle conversion and sea salt spray
>> PDF (1,10 MB)
DOI S0103-505320120050000062                                                    Published online: October 26, 2012

Chemical Constituents from Chirita longgangensis var. hongyao with Inhibitory Activity against Porcine Respiratory and Reproductive Syndrome Virus
Yao Su, Jun-Long Bi, Yue-Hu Wang, Ying Tan, Jun Yang, Hong-Xin Liu, Wei Gu, Ge-Fen Yin and Chun-Lin Long
J. Braz. Chem. Soc. 2012, 23, 1925.
Two new quinonoids and a new neolignan were isolated from stems of Chirita longgangensis var. hongyao
>> PDF (809 KB) /Supplementary Information (1,47 KB)
DOI S0103-505320120050000068                                                    Published online: October 30, 2012

Flavonoids from the Leaves of Deguelia utilis (Leguminosae): Structural Elucidation and Neuroprotective Properties
Dalglish G. de Oliveira, Cecília M. C. de Almeida, Consuelo Y. Y. e Silva, Mara S. P. Arruda, Alberto C. Arruda, Dielly C. F. Lopes, Elizabeth S. Yamada, Edmar T. da Costa and Milton N. da Silva
J. Braz. Chem. Soc. 2012, 23, 1933.

Five new compounds were isolated from the leaves of Deguelia utilis. A fraction containing all flavonoids was available to determine its neuroprotective action
>> PDF (671 KB) /Supplementary Information (728 KB)
DOI S0103-505320120050000065                                                    Published online: November 1, 2012

Three New Labdanes Isolated from Eragrostis viscosa
N'Soki N. Sebastião, Nelson Fernandes, Liliana Vieira, António J. G. Mendonça, Jorge F. Gaspar, Celia Martins, José Rueff, Carlos Diakanamwa and Dina I. M. D. de Mendonça
J. Braz. Chem. Soc. 2012, 23, 1940.

Three new labdanes methyl 8α,15-epoxylabdan-16β-oate, 8α,15-epoxylabdan-16β-ol and 8α,15-epoxy-16-norlabdan-13β-ol together with three known 8α,15-epoxylabdanes and two triterpenes were isolated from Eragrostis viscosa. 8α,15-Epoxylabdan-16β-ol was shown to be the most cytotoxic of the compounds tested
>> PDF (637 KB) /Supplementary Information (762 KB)
DOI S0103-505320120050000067                                                    Published online: November 1, 2012


Ionic Liquid Catalyzed Convenient Synthesis of Imidazo[1,2-a]quinoline under Sonic Condition
Devji S. Patel, Jemin R. Avalani and Dipak K. Raval
J. Braz. Chem. Soc. 2012, 23, 1951.

Environmentally benign protocol has been developed for the synthesis of imidazo[1,2-a]quinoline under sonic condition from readily available building blocks in presence of [DBU][Ac] (1,8-diazabicyclo[5.4.0]-undec-7-en-8-ium acetate), which is a convenient alternative to the existing procedures
>> PDF (301 KB) /Supplementary Information (1.20 MB)
DOI S0103-505320120050000051                                                      Published online: October 5, 2012

J. Braz. Chem. Soc.

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