G-Protein-Coupled Receptors: the 2012 Nobel Prize in Chemistry
The Royal Swedish Academy of Sciences awarded the 2012 Nobel Prize in Chemistry to the U.S. researchers Robert J. Lefkowitz, fom the Duke University Medical Center (North Carolina, USA) and to Brian K. Kobilka, from the Stanford University School of Medicine (California, USA) for their studies on the G-protein-coupled receptors (GPCRs).
Suppression
of the Hemolytic Effect of Mesoporous Silica Nanoparticles after
Protein Corona Interaction: Independence of the Surface Microchemical
Environment
Amauri
J. Paula, Diego Stéfani T. Martinez, Roberto T. Araujo Júnior,
Antonio G. Souza Filho and Oswaldo L. Alves
The effects induced by nanoparticles interacting
in biological fluids and with blood cells were determined by fine
and selective chemical interactions between these materials in nanoscale
and biomolecules. In this context, understanding and controlling these
interactions will be crucial to pave the way towards the application
of nanomaterials in nanomedicine and nanotoxicology. Details are discussed
in the Article byPaula
et al. on page 1807. (link below)
>>
Editorial(347
KB) G-Protein-Coupled
Receptors: the 2012 Nobel Prize in Chemistry Adriano D. Andricopulo and Glaucius Oliva
J.
Braz. Chem. Soc.2012, 23, 1767.
ARTICLES
Synthesis,
Crystal Structure and Biological Activity of Novel Diester Cyclophanes
Pengfei Zhang, Bingqin Yang, Xianwen Fang, Zhao Cheng and Meipan
Yang
J.
Braz. Chem. Soc.2012, 23, 1771.
Several
novel cyclophanes were synthesized by esterification reactions under
high dilution conditions. Some of these compounds have low antifungal
or antibacterial activities
Spatial
Structure of Eugenia dysenterica Based on Essential Oil Chemovariations
and Implications for Conservation and Management of the Genetic Diversity
of its Populations
Eliane C. Vilela, Thays C. Carvalho, Alessandra R. Duarte, Ronaldo R.
Naves, Suzana C. Santos,
José C. Seraphin and Pedro H. Ferri
J.
Braz. Chem. Soc.2012, 23, 1776.
Essential oils were used to study the spatial
structure of eight Eugenia dysenterica populations in central
Brazilian Cerrado. Differential patterns can be explained by the distinct
spatial rearrangement of the populations and may contribute to the
species management and conservation based only on oil chemovariations
Biosynthesis
of Two Dihydropyrrole-Polyketides from a Marine-Derived Penicillium citrinum
Stelamar Romminger, Eli F. Pimenta, Eduardo S. Nascimento, Antonio G.
Ferreira and
Roberto G. S. Berlinck
J.
Braz. Chem. Soc.2012,23, 1783.
Feeding
experiments using 13C-labeled precursors
were performed aim at investigating the biosynthesis of two dihydropyrrole-polyketides
isolated from a marine-derived Penicillium citrinum. The results
showed that the biosynthesis proceeds from acetate, methionine and ornithine
Probing
Topological Electronic Effects in Catalysis: Thiophene Adsorption
on NiMoS and CoMoS Clusters
Itamar Borges Jr. and Alexander M. Silva
J.
Braz. Chem. Soc.2012, 23, 1789.
Thiophene
adsorbed on NiMoS and CoMoS catalysts was studied with density functional
theory and a topological approach to probe electronic modifications.
The origin of the promoter effect, an enhancement of hydrodesulfurization
activity due to weaking of metal-sulfur bond strengths, was explained
Determination
of Sildenafil Citrate (Viagra®) in Various Pharmaceutical Formulations
by Flow Injection Analysis with Multiple Pulse Amperometric Detection
Antônio Carlos V. Lopes Júnior, Rita de Cássia Silva
Luz, Flávio S. Damos, Alexandre S. dos Santos, Diego L. Franco
and Wallans T. Pio dos Santos
J.
Braz. Chem. Soc.2012, 23, 1800.
Fast
and low-cost methodology for the determination of sildenafil in different
types of pharmaceutical samples using a flow injection analysis (FIA)
system with multiple pulse amperometric detection on a boron-doped diamond
electrode is presented. Excellent reproducibility and high analytical
frequency were obtained under these conditions
Suppression
of the Hemolytic Effect of Mesoporous Silica Nanoparticles after
Protein Corona Interaction: Independence of the Surface Microchemical
Environment
Amauri J. Paula, Diego Stéfani T. Martinez, Roberto T. Araujo
Júnior, Antonio G. Souza Filho and Oswaldo L. Alves
J.
Braz. Chem. Soc.2012, 23, 1807. (cover
article)
Bare
porous silica nanoparticles induce hemolysis in human red blood cells,
while protein coated nanoparticles resulted from their interaction with
blood plasma (the so called protein corona effect) completely prevent
the hemolytic effect
Evaluation
of Chemical Changes during Myrciaria cauliflora (Jabuticaba
Fruit) Fermentation by 1H NMR Spectroscopy and
Chemometric Analyses
Gilmara A. C. Fortes, Sara S. Naves, Pedro H. Ferri and Suzana
C. Santos
J.
Braz. Chem. Soc.2012, 23, 1815.
Metabolites
were monitored during jabuticaba fermentation by 1H
nuclear magnetic resonance and spectrophotometric assays. Multivariate
methods revealed the influences of alcohols and organic acids on the
extraction and stability of phenols and color properties
Influence
of Abiotic Factors on the Chemical Composition of Copaiba Oil (Copaifera multijuga
Hayne): Soil Composition, Seasonality and
Diameter at Breast Height
Paula C. S. Barbosa, Raquel S. Medeiros, Paulo T. B. Sampaio, Gil Vieira,
Larissa S. M. Wiedemann and Valdir F. Veiga-Junior
J.
Braz. Chem. Soc.2012, 23, 1823.
The chemical composition of
copaiba oils (Copaifera multijuga Hayne) is affected by soil
characteristics, but not seasonality or diameter at breast height
(DBH). Cluster analysis shows that caryophyllene and its oxide form
the main groups
Fast
Determination of Naproxen in Pharmaceutical Formulations by Batch
Injection Analysis with Pulsed Amperometric Detection
Jessica S. Stefano, Ana Paula de Lima, Rodrigo H. O. Montes, Eduardo
M. Richter
and Rodrigo A. A. Muñoz
J.
Braz. Chem. Soc.2012, 23, 1834.
A
fast method for naproxen determination in pharmaceutical formulations
using batch injection analysis with pulsed amperometric detection is
presented. High analytical frequency (90 h-1),
satisfactory accuracy and low limit of detection (0.3 μmol L-1)
were obtained
Synthesis
of N -Substituted Phthalimidoalkyl 1H
-1,2,3-Triazoles: a Molecular Diversity Combining Click Chemistry
and Ultrasound Irradiation
Moara T. da Silva, Ronaldo N. de Oliveira, Wagner O. Valença,
Fernanda C. G. Barbosa,
Mauro G. da Silva and Celso A. Camara
J.
Braz. Chem. Soc.2012, 23, 1839.
N-substituted
phthalimidoalkyl 1H-1,2,3-triazoles were obtained in good-to-excellent
yields (67-98%) through click chemistry protocol (Cu-AAC) at room temperature
using DMF, Et3N under ultrasound irradiation
Chemotaxonomic
Markers in Essential Oils of Hypenia (Mart. ex Benth.) R. Harley
Maria
T. Faria, Deomar P. Costa, Eliane C. Vilela, Dalva G. Ribeiro, Heleno
D. Ferreira,
Suzana C. Santos, José C. Seraphin and Pedro H. Ferri
J.
Braz. Chem. Soc.2012, 23, 1844.
Essential
oil chemovariations in the genus Hypenia suggest that cadinanes
and bicyclo-germacranes/aromadendranes are chemomarkers of sections
Densiflorae and Laxiflorae, respectively
7,8-Secolignans
from Schisandra neglecta and Their Anti-HIV-1 Activities
Xuemei Gao, Huaixue Mu, Ruirui Wang, Qiufen Hu, Liumeng Yang, Yongtang
Zheng, Handong Sun and Weilie Xiao
J.
Braz. Chem. Soc.2012, 23, 1853.
Four
new 7,8-secolignans (neglectahenols A-D) were isolated from leaves and
stems of Schisandra neglecta, and neglectahenols A-D showed modest
anti HIV-1 (human immuno-deficiency virus type 1) activities with therapeutic
index (TI) values of 58.65, 26.36, 23.71 and 25.85, respectively
Synthesis
of LaNiO3 Perovskite by the Modified
Proteic Gel Method and Study of Catalytic Properties in the Syngas
Production
José C. Santos, Marcelo J. B. Souza, Juan A. C. Ruiz, Dulce M.
A. Melo, Maria E. Mesquita
and Anne M. Garrido Pedrosa
J.
Braz. Chem. Soc.2012, 23, 1858.
The
temperature programmed reduction analysis of LaNiO3
and LaNiO3/Al2O3
showed that the Ni3+
of perovskite structure reduced in two steps and the peaks correspond
to successive changes in the structure, which are related to reduction:
Ni3+ to Ni2+
and Ni2+ to Ni0
Maria Estela Silva-Stenico, Felipe D. P. Vieira, Diego B. Genuário,
Caroline S. P. Silva,
Luiz Alberto B. Moraes and Marli Fátima Fiore
J.
Braz. Chem. Soc.2012, 23, 1863.
The
use of cyanobacteria to decolorize and possibly to degrade eleven types
of textile dyes was confirmed by mass spectrometry and resulted in completely
textile dye remotion
Solar Radiation Effect on the Complexation Capacity of Aquatic Humic
Substances with Metals
Camila A. Melo, Ana L. De Toffoli, Altair B. Moreira and Márcia
C. Bisinoti
J.
Braz. Chem. Soc.2012, 23, 1871.
The
effect of solar radiation in the complexation capacity of aquatic humic
substances (AHS) with Al3+, Cr3+,
CrO42-
and Ni2+ was evaluated. AHS were extracted
and characterized employing conventional techniques
Luiz C. C. Marques, Juliana O. Pereira, André D. Bueno, Valdo
S. Marques, Elizabete F. Lucas,
Claudia R. E. Mansur, A. L. C. Machado and Gaspar González
J.
Braz. Chem. Soc.2012, 23, 1880.
Asphaltic materials recovered from a subsea
petroleum production flowline during a pigging operation in Santos
Basin, Santa Catarina State, Brazil
Simultaneous
Separation of Ciprofloxacin, Norfloxacin and Ofloxacin by
Micellar Electrokinetic Chromatography
Gabriel Hancu, Aura Rusu, Brigitta Simon, Georgiana Boia and Árpád
Gyéresi
J.
Braz. Chem. Soc.2012, 23, 1889.
The
article studies the electrophoretic behavior of the most frequently
used fluoroquinolones (structurally related ciprofloxacin, norfloxacin
and ofloxacin) in order to achieve their simultaneous separation from
complex mixtures, by means of capillary zone electrophoresis respectively
MEKC
A
Simple Method to Evaluate, Correlate and Predict Boiling and Flash
Points of Alkynes
Justin M. Godinho, Felix A. Carroll and Frank H. Quina
J.
Braz. Chem. Soc.2012, 23, 1895.
Experimental
boiling point numbers (YBP) of alkynes can be
used to evaluate literature boiling point data, and YBP
values calculated from simple structure counts can be used to predict
alkyne boiling and flash points
Photocatalytic
Decomposition of Phenol by Nanocomposite of ZnS Nanoparticles and
Montmorillonite
Petr Praus, Jakub Matys and Ondrej Kozák
J.
Braz. Chem. Soc.2012, 23, 1900.
ZnS
nanoparticles were deposited on montmorillonite forming a stable nanocomposite,
which was used as a catalyst for the photodecomposition of phenol. Reaction
kinetics agreed with the pseudo-first reaction model confirming that
the high amounts of hydroxyl radicals were produced. The catalytic activity
of montmorillonite was not observed
Absolute
Quantification of Fatty Acid and Proximate Composition of Cow and
Goat Powdered Milks
Weliton P. Batiston, Swami A. Maruyama, Sandra T. M. Gomes, Jesuí
V. Visentainer, Nilson E. de Souza and Makoto Matsushita
J.
Braz. Chem. Soc.2012, 23, 1907.
Thermal
processes applied in foods can lead to a loss of their nutritional quality
due to the oxidation of their polyunsaturated fatty acids. Thus, the
main objective of the present study is the absolute quantification of
fatty acids from cow and goat powdered milks, through the application
of gas chromatography with a flame ionization detector (GC-FID)
Seasonal
Distribution of Airborne Trace Elements and Water-Soluble Ions
in São Paulo Megacity, Brazil
Gisele O. Da Rocha, Pérola C. Vasconcellos, Simone G. Ávila,
Davi Z. Souza, Eduardo A. O. Reis,
Pedro V. Oliveira and Odon Sanchez-Ccoyllo
J.
Braz. Chem. Soc.2012, 23, 1915.
This
work describes the seasonal distribution of important constituents of
PM10 particles (particulate matter less than 10
μm in diameter; major ions and trace elements) in São Paulo
Megacity, Brazil. Predominant sources were fuel burning, biomass burning,
gas-to-particle conversion and sea salt spray
Flavonoids
from the Leaves of Deguelia utilis (Leguminosae): Structural
Elucidation and Neuroprotective Properties
Dalglish G. de Oliveira, Cecília M. C. de Almeida, Consuelo Y.
Y. e Silva, Mara S. P. Arruda, Alberto C. Arruda, Dielly C. F. Lopes,
Elizabeth S. Yamada, Edmar T. da Costa and Milton N. da Silva
J.
Braz. Chem. Soc.2012, 23, 1933.
Five
new compounds were isolated from the leaves of Deguelia utilis.
A fraction containing all flavonoids was available to determine its
neuroprotective action
Three
New Labdanes Isolated from Eragrostis viscosa
N'Soki N. Sebastião, Nelson Fernandes, Liliana Vieira, António
J. G. Mendonça, Jorge F. Gaspar, Celia Martins, José Rueff,
Carlos Diakanamwa and Dina I. M. D. de Mendonça
J.
Braz. Chem. Soc.2012, 23, 1940.
Three
new labdanes methyl 8α,15-epoxylabdan-16β-oate, 8α,15-epoxylabdan-16β-ol
and 8α,15-epoxy-16-norlabdan-13β-ol together with three known
8α,15-epoxylabdanes and two triterpenes were isolated from Eragrostis
viscosa. 8α,15-Epoxylabdan-16β-ol was shown to be the
most cytotoxic of the compounds tested
Ionic
Liquid Catalyzed Convenient Synthesis of Imidazo[1,2-a]quinoline
under Sonic Condition
Devji S. Patel, Jemin R. Avalani and Dipak K. Raval
J.
Braz. Chem. Soc.2012, 23, 1951.
Environmentally
benign protocol has been developed for the synthesis of imidazo[1,2-a]quinoline
under sonic condition from readily available building blocks in presence
of [DBU][Ac] (1,8-diazabicyclo[5.4.0]-undec-7-en-8-ium acetate), which
is a convenient alternative to the existing procedures
